Title : BRCA MUTATIONS
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BRCA MUTATIONS
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From Tier Table Database
CDC Office of Public Health Genomics (OPHG) conducts horizon scanning (a systematic research method to find and follow novel technologies appearing in the literature) to identify and track the progress of genomic tests as they move from research into clinical and public health practice. As an aid in organizing horizon scanning results, OPHG ranks genomic tests, and family health history applications, by levels of evidence. See detail.
| Disease/Disorder | Test or Application | Intended Use | Tier Classified | Detail |
|---|---|---|---|---|
| BRCA-related cancer; hereditary breast and ovarian cancer | Consideration of multigene BRCA1/BRCA2 testing, following specified test criteria, risk assessment and counseling* | Breast/ovarian cancer risk prediction | Tier 1  |
|
| BRCA-related cancer; hereditary breast and ovarian cancer | Consideration of comprehensive BRCA1/BRCA2 testing of family member with greatest likelihood of mutation, following specified test criteria, risk assessment and counseling* | Breast/ovarian cancer risk prediction | Tier 1 |
|
| BRCA-related cancer; hereditary breast and ovarian cancer | Consideration of comprehensive BRCA1/BRCA2 testing in affected patients, following specified test criteria, risk assessment and counseling* | Breast/ovarian cancer risk prediction | Tier 1 |
|
| BRCA-related cancer; hereditary breast and ovarian cancer | BRCA1/BRCA2 testing for specific, known familial pathogenic mutation, following specified test criteria, risk assessment and counseling* | Breast/ovarian cancer risk prediction | Tier 1 |
|
| BRCA-related cancer; hereditary breast and ovarian cancer | Family history of breast and/or ovarian cancer in third-degree relative, who has additional specified familial risk factors* | Risk prediction for referral to further risk assessment, genetic counseling, and possibly genetic testing | Tier 1 |
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