How T-cells navigate the rough-and-tumble environment of the bloodstream

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How T-cells navigate the rough-and-tumble environment of the bloodstream

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Helper T cells move toward inflamed tissue using membrane protrusions that stabilize them and provide traction on the vasculature. Using high-resolution microscopy and global molecular analysis, scientists show that immature T cells lack these protrusions but that maturing T-cells switch on a gene expression program to create material to construct them.


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